Following the other thread about bomber killing weapons I would like to discuss it from another perspective.
This thread is specififcally intended NOT to include advanced weapons (SAM, R4M) or fighters (jet and rocket interceptors) or "what if" designs (Fw-187).
Assume that You are given responsibility to develop a defense strategy against the US 8th AAF offensive daylight bombing campaign, circling around the Bf-109G, Fw-190A, Me-410 and other planes historically aviable. With the technological and quantitative ressources aviable in the timeframe 1943 to 1945 You should inflict very heavy losses up to the point when daylight bombing must be reconsidered in the light of raising losses.
Note that by 1944, the USAAF does field long range escort fighters and increasing sizes of bombing formations.
How do You do?
My personal opinion is that properly defended, the USAAF cannot win the war of attrition. But I might very well be wrong.